The text analyzes the extent to which smallpox and measles epidemics provoked transformations in the ways in which workforces were acquired and used in colonial Amazonia from the mid-seventeenth to mid-eighteenth century, with an increase in slave raids on the indigenous population and the attempt to organize a trade route in African slaves to the region. It also explores how indigenous mortality rates at the end of the seventeenth century led to a concern with the region's defence and prompted the recruitment of soldiers from the Madeira islands.